Hi I am new to this, was diagnosed with RA in February 2013 now on Methotrexate due to two other medications making me sick. I have developed a cough over the past two weeks which is getting worse, not chesty just a dry cough and not sure if I should make appointment with GP. Feeling breathless, cough, high temperature. A severe skin rash. If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist. Uses. Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis that has not responded to other treatments. What type of cough medication. What type of cough medication can you take when on methotrexate? Asked 24 Aug 2010 by chloegrace Updated 24 August 2010 Topics cough, methotrexate. Details: it is only a normal cold but find it difficult to know what to take with out yet another visit to doctors. Answer this question. Responses (1) SU. suzanne66 24 Aug 2010. Visit your pharmacy and talk to the. Methotrexate can cause this, but generally it doesn’t get better unless the drug is stopped. Inflammation in the lung from RAr Sjogren’s can also cause a chronic cough. You should discuss with your doctor a referral to a pulmonary specialist for further evaluation. Methotrexate is a powerful medication that can be used for many serious conditions. MTX is an antineoplastic (anticancer) drug that is used in protocols to treat all kinds of cancers such as leukemias, lymphomas, and breast cancers. What is methotrexate? Methotrexate is an immuno-suppressive and anti-inflammatory medicine. This medicine is used to slow disease progression in Methotrexate is used to treat severe psoriasis (a skin disease in which red, scaly patches form on some areas of the body) that cannot be controlled by other treatments. Methotrexate can harm an unborn baby or cause birth defects, whether the mother or father is taking this medicine. If you are a woman, do not use methotrexate to treat psoriasis or rheumatoid arthritis if you are pregnant. In rare cases, methotrexate users may develop fibrosis and inflammation in the lungs, though this is unlikely to be related to adenosine release, says Dr. Chan. Report a dry cough, shortness of breath, or any other respiratory problem to your doctor.